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system1.comFor cold sores (herpes simplex labialis): a thousand mg daily for 12 months and a thousand mg three times each day for 6 months. The exception to the rule is the DOT1 family, members of which methylate K79 within the globular region of histone H3 and which are structurally not related to SET-domain proteins 4 - 6 Current work suggests that SET-domain-containing proteins methylate a few proteins in addition to histones (see later)