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Should you have virtually any concerns with regards to where and also the way to make use of lawyer article, it is possible to call us on the website. These tails are subject to several publish-translational covalent modifications, including acetylation, phosphorylation, ubiquitination, sumoylation and methylation (reviewed in 1 ). This pore is rimmed with several structurally conserved carbonyl oxygens in addition to the hydroxyl group of the invariant tyrosine from the carboxyl terminus of the SET domain (Figure 1 ).

The exception to the rule is the DOT1 family, members of which methylate K79 within the globular area of histone H3 and which are structurally not associated to SET-domain proteins 4 - 6 Latest work suggests that SET-domain-containing proteins methylate a few proteins along with histones (see later)