It's been in style for a very long time in cold regions akin to Northern France - Brittany (savory buckwheat crepes are their speciality), Russia (the little pancakes referred to as blinis were historically made with buckwheat), and Northern China - later launched to Japan, (soba noodles).

The exception to the rule is the DOT1 household, members of which methylate K79 in the globular region of histone H3 and which are structurally not associated to SET-domain proteins 4 - 6 Current work suggests that SET-area-containing proteins methylate just a few proteins in addition to histones (see later)